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  1. Plant flavonoids such as quercetin are useful for both the therapeutic and preventive care of a variety of illnesses. Nevertheless, their antitumor efficacy against KON oral cancer is still unknown. Therefore,...

    Authors: Sukannika Tubtimsri, Tiraniti Chuenbarn and Suwisit Manmuan
    Citation: BMC Complementary Medicine and Therapies 2025 25:34
  2. It seems that oxidative stress is involved in the occurrence and progression of non-alcoholic fatty liver disease (NAFLD). Considering the antioxidant features of Ellagic acid (EA), this study was designed to ...

    Authors: Sara Mighani, Rasoul Samimi, Mohamadreza Rashidi Nooshabadi, Seyed Amir Farzam, Hossein Khadem Haghighian and Maryam Javadi
    Citation: BMC Complementary Medicine and Therapies 2025 25:33
  3. The spreading of COVID-19 has posed a risk to global health, especially for lung cancer patients. An investigation is needed to overcome the challenges of COVID-19 pathophysiology and lung cancer disease. This...

    Authors: Md. Abul Barkat, Afreen Fatima, Bushra Riaz, Mohd. Zaheen Hassan, Tanveer Ahamad, Abdulkareem A. Alanezi, Harshita Barkat, Afaf F. Almuqati, Yahya I. Asiri and Sahabjada Siddiqui
    Citation: BMC Complementary Medicine and Therapies 2025 25:32
  4. Duranta erecta Linn. belongs to the Verbenaceae family and is primarily found in subtropical, tropical, and temperate climates. The plant has been reported to contain a variety of phytoconstituents, including iri...

    Authors: Marina Sobhy, Farid N. Kirollos, Sameh F. AbouZid, Nasser S. M. Ismail, Riham A. El-Shiekh and Essam Abdel-Sattar
    Citation: BMC Complementary Medicine and Therapies 2025 25:31
  5. Suhexiang (SHX) pill is widely used for treating acute ischemic stroke (AIS). Experimental and randomized controlled trials suggested that SHX pill was beneficial for patients with AIS. However, the effectiven...

    Authors: Xinxing Lai, Xuejiao Xiong, Qi Jia, Tingting Liu, Zhaowen Yang, Chi Zhang, Lingbo Kong, Kegang Cao, Ting Dong, Caixia Fang, Jianwen Ge, Li Dong, Zhitao Zong, Sisi Chen, Yuhong Ma, Xue Bai…
    Citation: BMC Complementary Medicine and Therapies 2025 25:30
  6. Amorpha fruticosa was used for treating burn, ambustion, carbuncle, and eczema in the traditional Chinese medicine. Although more and more attention has been paid to its biological activity recently, the antitumo...

    Authors: Yixian Liu, Xiaojun Zhang, Jiacong Hao, Ying Zhao, Min Zou, Huiping Chen and Jintao Zhang
    Citation: BMC Complementary Medicine and Therapies 2025 25:29
  7. Atherosclerosis serves as the fundamental pathology for a variety of cardiovascular disorders, with its pathogenesis being closely tied to the complex interplay among lipid metabolism, oxidative stress, and in...

    Authors: Zhaohui Gong, Haixin Yang, Li Gao, Yi Liu, Qingmin Chu, Chuanjin Luo, Liang Kang, Huiqi Zhai, Qiang Xu, Wei Wu, Nan Li and Rong Li
    Citation: BMC Complementary Medicine and Therapies 2025 25:28
  8. Oral squamous cell carcinoma (OSCC) ranks as the sixth most common malignancy globally. Cisplatin is the standard chemotherapy for OSCC, but resistance often reduces its efficacy, necessitating new treatments ...

    Authors: Amany E. Ragab, Ghada M. Al-Ashmawy, Sherin R. El Afify, Ola A. El-Feky and Amera O. Ibrahim
    Citation: BMC Complementary Medicine and Therapies 2025 25:25
  9. Heart failure (HF) is a complex syndrome marked by considerable expenditures and elevated mortality and morbidity rates globally. Shenmai injection (SMI), a form of Traditional Chinese Medicine-based therapy, ...

    Authors: Lin Li, Senjie Zhong, Jiahao Ye, Siyuan Hu, Xiajun Xiong, Guangyu Chen and Zhixi Hu
    Citation: BMC Complementary Medicine and Therapies 2025 25:24
  10. Children are anxious when hospitalized due to being away from home and undergoing treatment.This anxiety has an effect on their disease process, treatment, growth and development.Children’s anxiety has an effe...

    Authors: Fatemeh Abdi, Ali Karamoozian, Mostafa Lotfilou, Fatemeh Gholami, Negin Shaterian, Alireza Abasi Niasar, Ehsan Aghapour and Mohammadamin Jandaghian-Bidgoli
    Citation: BMC Complementary Medicine and Therapies 2025 25:23
  11. This study evaluated in vitro antigiardial activity in four Indonesian plants (Archidendron fagifolium, Diospyros sumatrana, Piper betle and Shorea sumatrana) extracted in methanol, methanol-tetrahydrofuran, and ...

    Authors: Radka Pecková, Karel Doležal, Bohumil Sak, Dana Květoňová, Martin Kváč, Ivan Petřík, Wisnu Nurcahyo and Ivona Foitová
    Citation: BMC Complementary Medicine and Therapies 2025 25:22
  12. Hexaflumuron (HFM), a common pesticide, can disrupt the immune system and cause oxidative stress. This study investigated the potential of Physalis peruviana L. calyces extract (PP) to counteract these effects in...

    Authors: Mona M. Hashem, Eman I. Hassanen, Neven H. Hassan, Marwa A. Ibrahim, Marwa Y. Issa, Mohamed A. Farag and Sherif A. Hamdy
    Citation: BMC Complementary Medicine and Therapies 2025 25:21
  13. Anzi Tiaochong Fang (ATF) is a traditional Chinese medicine (TCM) Fangji widely used to treat antiphospholipid syndrome-related recurrent pregnancy loss (APS-RPL). This study aimed to identify the quality mark...

    Authors: Shan He, Fei Ma, Jia Li, Da-yan Liu, Zhi-wei Wang, Peng-dian Chen, Jia-man Wu, Hong Chang and Yan Ning
    Citation: BMC Complementary Medicine and Therapies 2025 25:20
  14. Patient engagement (PE) in clinical trials has gained importance yet remains uncommon, particularly in patients with mild cognitive impairment (MCI), a critical precursor to Alzheimer’s disease (AD). Cannabidi...

    Authors: Antonia Keck, Julia-Sophia Scheuermann, Petra Scheerbaum, Elmar Graessel and Kirsten R. Müller-Vahl
    Citation: BMC Complementary Medicine and Therapies 2025 25:19
  15. This study investigated whether a sound intervention tuned to 432 Hz (Hz) yields differential effects on cardiovascular parameters and psychological outcomes compared to 443 Hz, which is the concert pitch in G...

    Authors: Anna Hohneck, Ánxelo Maia Rodríguez, Simone Weingärtner, Kirsten Merx, Felicitas Sarodnick, Fritjof von Gagern, Athanasios Mavratzas, Iris Burkholder, Gerhard Schumacher, Wolf-Karsten Hofmann and Ralf-Dieter Hofheinz
    Citation: BMC Complementary Medicine and Therapies 2025 25:18
  16. Amongst all neoplastic diseases, breast cancer represents a major cause of death among the female population in developed and developing countries. Since alkaloid drugs are commonly used in chemotherapy to man...

    Authors: Kolawole A. Olofinsan, Heidi Abrahamse and Blassan P. George
    Citation: BMC Complementary Medicine and Therapies 2025 25:17
  17. Demonstrating a positive impact of educational programs on clinical care outcomes is challenging. We assess students' knowledge, attitudes, and behaviors as short-term outcomes of integrating a structured Trad...

    Authors: Sunny Jui-Shan Lin, Shung-Tai Ho, Yi-Chang Su, Chien-Sung Tsai, Shu-Meng Cheng, Cheng-Yi Cheng, Tso-Chou Lin and Chien-Jung Lin
    Citation: BMC Complementary Medicine and Therapies 2025 25:16
  18. This study aimed to investigate the synergistic effects of the chemotherapy drug Carfilzomib (CFZ) and Pistachio hull extract on the SK-BR3 breast cancer cell line.

    Authors: Zahra Mirzaei, Sadegh Zarei, Ahmadreza Sayadi, Reza Hosseiniara, Mojgan Noroozi Karimabad and Mehdi Mahmoodi
    Citation: BMC Complementary Medicine and Therapies 2025 25:15
  19. Reduced cardiac autophagy, inflammation, and apoptosis contribute to cardiovascular complications caused by metabolic syndrome (MetS). It is documented that the nuclear receptor 4A2 (NR4A2) could modulate auto...

    Authors: Xiyan Dai, Bo Liang and Yaolin Sun
    Citation: BMC Complementary Medicine and Therapies 2025 25:14
  20. Currently, there is no agreed-upon data collection tool for comprehensively structured documentation of Iranian traditional medicine (ITM) from the information management perspective. As ITM practice varies si...

    Authors: Razieh Mirzaeian, Abdolghader Bahraini and Hadi Kazemi-Arpanahi
    Citation: BMC Complementary Medicine and Therapies 2025 25:13
  21. The integration of herbal and orthodox medicines has gained momentum in global health, ensuring improved management of infectious diseases like malaria. This study explored the experiences of medical herbalist...

    Authors: Irene G. Ampomah, Susan Devine, Genevieve A. Ampomah and Theophilus I. Emeto
    Citation: BMC Complementary Medicine and Therapies 2025 25:11
  22. The demand for health management services has grown among individuals with physical disabilities. It is noteworthy that a significant proportion of this demographic has sought the services of traditional Korea...

    Authors: Chihyoung Son, Jong-hyun Kim, Eunkyung Yoon, Eunji Ahn, Minjung Park and Dongsu Kim
    Citation: BMC Complementary Medicine and Therapies 2025 25:10
  23. This study intended to explore whether the protective effect safflower yellow injection (SYI) on myocardial ischemia-reperfusion (I/R) injury in rats mediated of the NLRP3 inflammasome signaling.

    Authors: Lingmei Li, Ce Cao, Hao Guo, Li Lin, Lei Li, Yehao Zhang, Gaojie Xin, Zixin Liu, Shujuan Xu, Xiao Han, Qiong Zhang and Jianhua Fu
    Citation: BMC Complementary Medicine and Therapies 2025 25:9
  24. Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease (NAFLD) characterized by damage and inflammation of hepatocytes. Some medicinal plants have shown antioxidant and anti-i...

    Authors: Mohamed Kamal Shaker, Mohamed Hassany, Basem Eysa, AbdulMoneim Adel, Ahmed Zidan and Shahnaz Mohamed
    Citation: BMC Complementary Medicine and Therapies 2025 25:8
  25. Pseudomonas aeruginosa is an opportunistic pathogen belonging to the γ-proteobacteria family, known to cause pneumonia linked with ventilator use and nosocomial infections. With the increasing prevalence of antib...

    Authors: Deniz M. Al-Tawalbeh, Jafar M. Alawneh, Waleed Momani and Amal Mayyas
    Citation: BMC Complementary Medicine and Therapies 2025 25:7
  26. Evidence about rehabilitation of post COVID-19 condition is scarce. Yoga has been found beneficial in other chronic conditions and can be delivered in a digital format at home. The aim of the study was to expl...

    Authors: Marie Lundberg, Leonie Klompstra, Lotti Orwelius, Mirjam Schimanke, Cecilia Olsson and Anna Strömberg
    Citation: BMC Complementary Medicine and Therapies 2025 25:6
  27. Gastrointestinal diseases in children and adolescents lead to a considerable impairment of the quality of life of children and parents. Accordingly, there are considerable socio-economic consequences for the f...

    Authors: Ayşegül Bükülmez, Ayşegül Köroğlu and Melike Taşdelen Baş
    Citation: BMC Complementary Medicine and Therapies 2025 25:5
  28. The integration of traditional Chinese medicine (TCM) into emergency health systems in China serves as a model for global policy development and refining the inclusion of traditional medicine in health emergen...

    Authors: Yujing Zhang, Xia Tian, Zhao Chen, Ziteng Hu, Huizhen Li, Xingyu Zong, An Li, Fuqiang Zhang, Yaxin Chen, Haili Zhang, Lijiao Yan, Ning Liang, Nannan Shi and Yanping Wang
    Citation: BMC Complementary Medicine and Therapies 2025 25:4
  29. Given the crucial role of integrating acupuncture treatment into primary care for managing chronic diseases, this study endeavors to identify the utilization of acupuncture among chronic disease patients seeki...

    Authors: Su Yeon Lee, Soo Jeung Choi, Hyea Bin Im, Dain Choi and Dongwoon Han
    Citation: BMC Complementary Medicine and Therapies 2025 25:3
  30. Frailty is a common geriatric syndrome worldwide, and its early identification and intervention have important clinical significance. Resistance training has been recommended as an efficient means to combat lo...

    Authors: Wen Zhong, Wei Huang, Hua Deng, Shuang Qiu, Qiyue Yang and Huanan Jia
    Citation: BMC Complementary Medicine and Therapies 2025 25:1
  31. The treatment of advanced colorectal cancer (CRC) has progressed slowly, with chemotherapy combined with targeted therapy being the first-line treatment for the disease, but the improvement in efficacy is not ...

    Authors: Jingyuan Wu, Yuansha Ge, Guanghui Zhu, Ruike Gao, Xiaoyu Zhu, Ying Zhang and Jie Li
    Citation: BMC Complementary Medicine and Therapies 2024 24:429
  32. Sarcopenia is a disease primarily characterized by age-related loss of skeletal muscle mass, muscle strength, and/or decline in physical performance. Sarcopenia has an insidious onset which can cause functiona...

    Authors: Hao Li, Li Zhou, Xin Zhang, Qian Wen, Li Tian, Han Yang, Xirong Chen, Jinghan Yuan, Ning Li, Bingmei Zhu, Lin Zhang and Lingyun Lu
    Citation: BMC Complementary Medicine and Therapies 2024 24:428
  33. A precise observation is that the cervix’s solid tumors possess hypoxic regions where the oxygen concentration drops below 1.5%. Hypoxia negatively impacts the host’s immune system and significantly diminishes...

    Authors: Behrouz Ebadi Sharafabad, Asghar Abdoli, Parisa Jamour and Azita Dilmaghani
    Citation: BMC Complementary Medicine and Therapies 2024 24:427
  34. This qualitative study aimed to explore patients’ experiences with a novel treatment approach for endometriosis-associated pain, termed ‘sinosomatics’. Specifically, it sought to understand women’s experiences...

    Authors: Anna Limmer, Annemarie Weber, Elisabeth Olliges, Jana Kraft, Florian Beissner, Christine Preibisch and Karin Meissner
    Citation: BMC Complementary Medicine and Therapies 2024 24:426
  35. L-arginine (Arg) is a semi-essential amino acid that can be used as a key mediator for the release of growth hormone (GH), insulin-like growth factor-1(IGF-1), and other growth factors. In this study, we compr...

    Authors: Forough Saki, Nima Rahimikashkooli, Moein Masjedi, Sanaz Dastghaib and Farhad Koohpeyma
    Citation: BMC Complementary Medicine and Therapies 2024 24:425
  36. Amphetamine-type stimulant (ATS) abuse is strongly associated with an elevated risk of HIV infection and transmission. Antiretroviral therapy (ART) serves as the primary approach for managing HIV infection and...

    Authors: Tao Li, Jun Liu, Zuoliang Li, Shoujun Wang, Su Zhang, Xin Zhou and Yulan Ren
    Citation: BMC Complementary Medicine and Therapies 2024 24:424
  37. Exercise is a promising nonpharmacological intervention to delay the progression of cognitive impairment and improve physical function and sleep quality in patients, but the evidence remains inconclusive.

    Authors: Ran Gao, Chieko Greiner, Hirochika Ryuno and Xuanrong Zhang
    Citation: BMC Complementary Medicine and Therapies 2024 24:423
  38. As the primary cause of various preventable illnesses, smoking results in approximately five million premature deaths each year in the US and a multitude of adults living with serious illness. The majority of ...

    Authors: Chengguo Xing, John Malaty, Melissa Bou Malham, Frank A. Orlando, Allison Lynch, Zhiguang Huo, Magda François, Roberto Firpi-Morell, Carla L. Fisher, Demetra D. Christou and Ramzi G. Salloum
    Citation: BMC Complementary Medicine and Therapies 2024 24:422
  39. Acute postoperative pain is often reported after repair of inguinal hernia and can negatively impact patient satisfaction and clinical outcomes. This includes delayed wound healing, longer hospitalization, and...

    Authors: Hosein Bagheri, Mobin Mottahedi, Seyedeh Solmaz Talebi, Sara Mehralizade and Hossein Ebrahimi
    Citation: BMC Complementary Medicine and Therapies 2024 24:421
  40. Chemotherapy administrations for cervical malignancy possess a variety of unfavorable influences on the human body. Scientists are interested in microbial-derived biomolecules or postbiotics as an alternative ...

    Authors: Abbas Asoudeh-Fard, Moein Yeylagh Beygi, Asghar Parsaei, Milad Mohkam, Mohadeseh Asoudeh-Fard and Ahmad Gholami
    Citation: BMC Complementary Medicine and Therapies 2024 24:420
  41. Bongkrekic acid is a rare mitochondrial toxin produced by the Burkholderia cocovenenans subsp. Bongkrekic acid poisoning has a case fatality rate of more than 50%, and progresses rapidly to multiple organ failure...

    Authors: Mengdi Shi, Mei Zeng, Aerbusili Genjiafu, Xiangxing Zhang, Lanlan Guo, Ruikai Shang, Zhiqiang Zhou, Xiangdong Jian and Lingjia Yu
    Citation: BMC Complementary Medicine and Therapies 2024 24:419
  42. Esophageal achalasia, a primary disorder impacting the lower esophageal sphincter (LES), presents symptoms such as dysphagia, regurgitation, chest pain, and weight loss. Traditional treatments, including calci...

    Authors: Wen-Harn Koh, Li-Wei Lin, Ting-I Lin, Ching-Wen Liu, Li-Ching Chang, I-Chun Lin, Ming-Shiang Wu and Ching-Chung Tsai
    Citation: BMC Complementary Medicine and Therapies 2024 24:417
  43. Mucositis is one of the common side effects of chemotherapy. This study aimed to identify the effects of honey on oral care interventions to reduce mucositis scores among children undergoing chemotherapy.

    Authors: Ikeu Nurhidayah, Yeni Rustina, Sutanto Priyo Hastono and Henny Suzana Mediani
    Citation: BMC Complementary Medicine and Therapies 2024 24:415
  44. While more and more people tend to use herbal products thinking they are safer than conventional western medicine, the reality is other. If natural products are bio-active and possess potential therapeutic act...

    Authors: Anthony Cnudde, Camille Allely, Natacha Biset, Pierre Champy, Nathalie Fouilhé, Fanny Huret, Sibi Lawson, Aline Mercan, Doris Pascale Noukela Noumi, Serge Michalet, Andrea Montis, Stephanie Pochet, Audrey Schils, Cecilia Tangeten, Michel Tod, Pierre Van Antwerpen…
    Citation: BMC Complementary Medicine and Therapies 2024 24:414
  45. Brennnesselwurzel (Urtica dioica L.) is recognized for its diverse pharmacological properties. With a range of chemical constituents, such as vitamins, minerals, phenolic compounds, fibers, and amino acids, Brenn...

    Authors: Amr Elkelish, Abdelghafar M. Abu-Elsaoud, Alaa M. Alqahtani, Mohammad El-Nablaway, Norah Al harthi, Najwa Al harthi, Sulaiman Lakoh, Essa M. Saied and Mai Labib
    Citation: BMC Complementary Medicine and Therapies 2024 24:413