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Table 4 Protective effects of PE and three phenylbutenoids against H₂O₂-induced apoptosis in C2C12 myoblast cells

From: Phytochemical analysis and biological effects of Zingiber cassumunar extract and three phenylbutenoids: targeting NF-κB, Akt/MAPK, and caspase-3 pathways

Compound/Extract

IC50 (µg/mL)

Inhibition of apoptosis

Compound D

23.7 ± 2.5b

Compound D acetate

20.7 ± 1.0b

DMPBD

12.4 ± 0.7a

PE

11.6 ± 0.6a

  1. The results are expressed as mean ± SEM (n = 4). Statistical analysis was performed using one-way ANOVA followed by LSD post-hoc test. Significant differences among all samples are indicated by different letters in each column (p < 0.05). NAC (50 mM) exhibited 77.29 ± 0.97% inhibition of apoptosis. Compound D: (E)-1-(3,4-dimethoxyphenyl)but-3-en-1-ol, compound D acetate: (E)-1-(3,4-dimethoxyphenyl)but-3-en-1-yl acetate, DMPBD: (E)-(3,4-dimethoxyphenyl)butadiene, PE: phenylbutenoid extract
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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