Compound/Extract | IC50 (µg/mL) |
|---|
Inhibition of NO | Inhibition of TNF-α | Inhibition of IL-1β |
|---|
Compound D | 51.8 ± 4.3d | 52.8 ± 4.5c | 47.6 ± 3.5c |
Compound D acetate | 36.2 ± 2.8c | 39.6 ± 1.6b | 32.2 ± 2.6b |
DMPBD | 16.3 ± 0.6b | 37.2 ± 1.2b | 17.7 ± 1.2a |
PE | 7.2 ± 0.4a | 23.4 ± 1.9a | 19.8 ± 1.6a |
- The results are expressed as mean ± SEM (n = 4). Statistical analysis was performed using one-way ANOVA followed by LSD post-hoc test. Significant differences within each column are indicated by different letters (p < 0.05). Dexamethasone (1 µg/mL) showed 99.4 ± 3.8% inhibition of NO, 87.3 ± 8.7% inhibition of TNF-α, and 96.2 ± 1.9% inhibition of IL-1β. NO: nitric oxide, TNF-α: tumor necrosis factor-α, IL-1β: interleukin-1β, compound D: (E)-1-(3,4-dimethoxyphenyl)but-3-en-1-ol, compound D acetate: (E)-1-(3,4-dimethoxyphenyl)but-3-en-1-yl acetate, DMPBD: (E)-(3,4-dimethoxyphenyl)butadiene, PE: phenylbutenoid extract
