Table 1 Cholinesterase inhibitory activity of extracts, fractions (in 500 µg/mL), and compounds 1–5 (in 40 µg/mL) ^a of S. aristata

SADE

3.66 ± 0.69

35.86 ± 1.77

SAHE

62.74 ± 3.57 (IC₅₀ = 339.8 µg/mL, 95% CI: 294.9-384.8)^b

15.21 ± 1.15

Fraction I

23.42 ± 0.09

5.72 ± 1.60

Fraction II

21.66 ± 0.19

0.81 ± 0.12

Fraction III

19.48 ± 0.11

1.12 ± 0.31

Fraction IV

27.77 ± 0.31

17.93 ± 2.10

Fraction V

6.49 ± 0.06

0.90 ± 0.21

Compound 1

10.91 ± 1.30

18.41 ± 2.72

Compound 2

11.93 ± 2.51

5.86 ± 0.91

Compound 3

6.55 ± 0.22

10.97 ± 0.18

Compound 4

11.54 ± 0.19

10.97 ± 0.77

Compound 5

10.03 ± 0.08

3.08 ± 0.18

Donepezil

89.11 ± 3.73 (IC₅₀ = 0.02 µM, 95% CI: 0.01–0.03)

86.60 ± 4.81 (IC₅₀ = 1.92 µM, 95% CI: 1.82–2.03)