The potential value of traditional Chinese medicine monomers in cerebral ischemia–reperfusion injury: a network meta-analysis based on animal model

Table 6 Results of meta-regression analysis of dose and course of treatment

Outcomes	TCM monomers	Regression coefficients SMD [95% CI]
Outcomes	TCM monomers	Dose	Duration
mNSS	Astragaloside IV	−0.42 [−1.08, 0.23]	−0.71 [−1.35, −0.08]
	Baicalein	−1.43 [−2.81, −0.05]	−0.67 [−1.92, 0.58]
	Curcumin	−0.49 [−1.49, 0.51]	0.41 [−0.56, 1.39]
	Ginsenoside	−0.38 [−1.14, 0.38]	−0.02 [−0.91, 0.87]
	Hydroxysafflor yellow A	−1.68 [−3.16, −0.19]	−1.15 [−2.77, 0.48]
	Paeoniflorin	−2.94 [−4.37, −1.51]	−3.71 [−5.21, −2.22]
	Puerarin	−2.77 [−3.60, −1.94]	−2.78 [−3.56, −1.99]
	Quercetin	−0.09 [−0.93, 0.76]	−2.48 [−4.74, −0.24]
	Salvianolic Acid	−2.60 [−4.38, −0.82]	−3.34 [−5.16, −1.51]
	Sinomenine	−1.39 [−2.71, −0.09]	−0.33 [−1.93, 1.29]
Longa	Baicalein	−3.83 [−12.00, 4.07]	−3.00 [−7.75, 1.74]
	Curcumin	−2.16 [−15.58, 10.03]	−0.55 [−5.21, 4.09]
	Ginsenoside	−1.17 [−4.16, 1.80]	−1.55 [−4.07, 0.99]
	Quercetin	−0.43 [−4.83, 3.72]	−0.48 [−5.11, 4.10]
	Salvianolic Acid	0.15 [−5.18, 5.31]	−0.17 [−4.78, 4.38]
	Scutellarin	−3.09 [−8.55, 2.13]	−3.33 [−8.35, 1.65]
	Sinomenine	−0.23 [−5.14, 4.51]	−0.55 [−5.13, 4.08]
BWC	Baicalein	−1,17 [−12.61, 8.46]	−1.65 [−17.76, 8.78]
	Salvianolic Acid	−3.56 [−19.08, 15.14]	−3.75 [−6.64, 0.11]
	Sinomenine	−1.25 [−8.44, 4.77]	−0.61 [−8.92, 12.29]
IV	Baicalein	−2.68 [−29.69, 29.82]	-
	Bilobalide	−5.39 [−25.64, 11.31]	-
	Puerarin	−2.02 [−14.28, 8.10]	-

Note. The significant findings were displayed in bold. Regarding IV, the course of treatment was the same in all studies, and as a result, meta-regression was not performed

ISSN: 2662-7671