Table 1 Differential metabolites associated with depression
Name | Class | HMDB | RT (min) | P value | VIP | Tread |
|---|---|---|---|---|---|---|
N-alpha-acetyllysine | Carboxylic acids and derivatives | 0000446 | 7.34 | 1.22E-05 | 2.6 | ↑ |
N-acetylglutamic acid | Carboxylic acids and derivatives | 0001138 | 7.95 | 1.06E-04 | 2.52 | ↑ |
Homocitrulline | Carboxylic acids and derivatives | 0000679 | 7.37 | 1.48E-04 | 2.5 | ↑ |
2-methylcitric Acid | Carboxylic acids and derivatives | 0000379 | 9.09 | 0.0027 | 2.25 | ↑ |
Indole-3-methyl acetate | Indoles and derivatives | 0029738 | 5.99 | 0.0046 | 2.2 | ↑ |
Hydroxyproline | Carboxylic acids and derivatives | 0000725 | 6.5 | 0.0064 | 2.14 | ↓ |
Glycerol-myristate | Glycerolipids | 0011561 | 10.5 | 0.0083 | 2.09 | ↓ |
Palmitoylethanolamide | Carboximidic acids and derivatives | 0002100 | 11.03 | 0.0093 | 2.07 | ↓ |
Mannose 6-phosphate | Organooxygen compounds | 0001078 | 9.08 | 0.0102 | 2.07 | ↑ |
Deoxycytidine | Organic oxoanionic compounds | 0000014 | 2.5 | 0.0105 | 2.05 | ↓ |
Ursodeoxycholic acid (UDCA) | Steroids and steroid derivatives | 0000946 | 8.54 | 0.0112 | 2.06 | ↓ |
Murocholic acid (MoCA) | Steroids and steroid derivatives | 0000811 | 8.23 | 0.0126 | 2.02 | ↓ |
IDP | Purine nucleotides | 0003335 | 9.46 | 0.0130 | 2 | ↑ |
Thyronine | Carboxylic acids and derivatives | 0000667 | 8.39 | 0.0133 | 2.02 | ↓ |
Chenodeoxycholic acid (CDCA) | Steroids and steroid derivatives | 0000518 | 8.54 | 0.0135 | 2.03 | ↓ |
Galactose 1-phosphate | Organooxygen compounds | 0000645 | 9.42 | 0.0161 | 1.77 | ↑ |
Inosine-monophosphate | Purine nucleotides | 0000175 | 8.99 | 0.0172 | 1.97 | ↑ |
Beta-ursodeoxycholic acid (β-UDCA) | Steroids and steroid derivatives | 0000686 | 8.54 | 0.0183 | 1.96 | ↓ |
N-acetylneuraminic acid | Organooxygen compounds | 0000230 | 7.38 | 0.0229 | 1.9 | ↑ |
Beta-hyodeoxycholic acid (β-HDCA) | Steroids and steroid derivatives | 0000664 | 8.84 | 0.0258 | 1.89 | ↓ |
D-sedoheptulose 7-phosphate | Organooxygen compounds | 0001068 | 9.7 | 0.0263 | 1.87 | ↑ |
ADPG | Purine nucleotides | 0006557 | 8.75 | 0.0339 | 1.84 | ↑ |
Corticosterone | Steroids and steroid derivatives | 0001547 | 6.96 | 0.0353 | 1.81 | ↑ |
Gamma-linolenic acid | Fatty Acyls | 0003073 | 10.99 | 0.0454 | 1.78 | ↑ |
D-ribose 5-phosphate | Organooxygen compounds | 0001548 | 8.97 | 0.0482 | 1.73 | ↑ |
Ricinoleic acid | Fatty Acyls | 0034297 | 9.94 | 0.0478 | 1.71 | ↓ |